All Fungi-Nail products are nail polish and acrylic friendly. Fungi-Nail is applied to the skin around your cuticle, around the sides of your nail, and underneath the tip of the nail where accessible with the applicator. Fungi-Nail is not applied to the nail itself, so it will not damage your manicure or pedicure. If you do choose to polish your nails, Fungi-Nail should be applied and allowed to dry before applying nail polish or acrylics.